Kenneth E Bernstein Selected Research

Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)

1/2022	The non-cardiovascular actions of ACE.
1/2020	Overexpression of ACE in Myeloid Cells Increases Immune Effectiveness and Leads to a New Way of Considering Inflammation in Acute and Chronic Diseases.
1/2020	Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
12/2019	Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis.
1/2019	Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.
1/2018	Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.
11/2017	Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.
7/2015	Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
4/2015	The intrarenal generation of angiotensin II is required for experimental hypertension.
12/2014	Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition.

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Kenneth E Bernstein Research Topics

Disease

24	Hypertension (High Blood Pressure) 01/2022 - 02/2005
9	Inflammation (Inflammations) 01/2022 - 05/2014
7	Neoplasms (Cancer) 01/2021 - 06/2007
5	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 01/2018
5	Melanoma (Melanoma, Malignant) 01/2020 - 06/2007
4	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 10/2006
4	Fibrosis (Cirrhosis) 11/2017 - 09/2004
4	Sudden Death 11/2011 - 09/2004
3	Atherosclerosis 01/2020 - 04/2010
3	Neuroinflammatory Diseases 01/2020 - 08/2015
3	Cardiac Arrhythmias (Arrythmia) 11/2011 - 09/2004
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2020
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 10/2020
2	Infections 01/2021 - 01/2017
2	Cognitive Dysfunction 12/2020 - 03/2014
2	Vascular Diseases (Vascular Disease) 12/2020 - 01/2016
2	Bacterial Infections (Bacterial Infection) 01/2020 - 01/2017
2	Albuminuria 10/2018 - 01/2018
2	Ventricular Tachycardia 11/2011 - 07/2011
2	Anemia 04/2011 - 04/2004
2	Cardiomegaly (Heart Hypertrophy) 02/2010 - 02/2008
2	Hypotension (Low Blood Pressure) 06/2008 - 04/2004
1	Heart Failure 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Bacteremia 01/2021
1	Dementia (Dementias) 12/2020
1	Metabolic Diseases (Metabolic Disease) 12/2020
1	Proteostasis Deficiencies 12/2020
1	Gliosis 01/2020
1	Disease Progression 01/2020
1	Necrosis 01/2020
1	Atherosclerotic Plaque (Atheroma) 12/2019
1	Wounds and Injuries (Trauma) 11/2018
1	Cicatrix (Scar) 11/2018

Drug/Important Bio-Agent (IBA)

23	Angiotensin IIIBA 01/2022 - 04/2004
22	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2022 - 09/2004
8	SaltsIBA 01/2022 - 04/2015
6	SodiumIBA 01/2021 - 05/2013
6	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2017 - 12/2014
5	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2022 - 01/2017
3	Epithelial Sodium ChannelsIBA 01/2022 - 10/2018
3	Apolipoproteins E (ApoE)IBA 01/2020 - 04/2010
3	Peptides (Polypeptides)IBA 01/2020 - 04/2004
3	Amyloid (Amyloid Fibrils)IBA 01/2020 - 03/2014
3	Angiotensin IIBA 10/2018 - 02/2008
3	goralatideIBA 10/2018 - 04/2004
3	CytokinesIBA 08/2015 - 02/2008
3	Proteins (Proteins, Gene)FDA Link 10/2014 - 03/2014
2	Pharmaceutical PreparationsIBA 01/2021 - 09/2010
2	Biological ProductsIBA 12/2020 - 06/2008
2	Insulin (Novolin)FDA Link 01/2020 - 02/2005
2	Acetates (Acetic Acid Esters)FDA Link 12/2019 - 02/2010
2	Desoxycorticosterone (Deoxycorticosterone)IBA 12/2019 - 02/2010
2	Losartan (Cozaar)FDA LinkGeneric 11/2018 - 07/2015
2	CollagenIBA 11/2018 - 01/2016
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2017 - 08/2015
2	Superoxides (Superoxide)IBA 01/2017 - 01/2016
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 07/2015 - 07/2007
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2014 - 05/2013
2	Connexin 43 (Connexin43)IBA 11/2011 - 07/2011
2	ReninIBA 07/2007 - 07/2007
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2022
1	Vasoconstrictor AgentsIBA 01/2022
1	Angiotensin Receptor AntagonistsIBA 01/2021
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2021
1	Metalloproteases (Metalloproteinases)IBA 01/2021
1	Vascular Endothelial Growth FactorsIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	compound 21IBA 10/2020
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	Desoxycorticosterone Acetate (DOCA)FDA Link 12/2019
1	Adenosine (Adenocard)FDA LinkGeneric 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Purinergic P2X7 ReceptorsIBA 01/2019
1	STAT1 Transcription FactorIBA 01/2019
1	Hydralazine (Apresoline)FDA LinkGeneric 11/2018
1	Ramipril (Altace)FDA LinkGeneric 11/2018
1	Phosphotransferases (Kinase)IBA 11/2018
1	Streptozocin (Streptozotocin)FDA Link 10/2018
1	Low Density Lipoprotein Receptor-Related Protein-2IBA 01/2018
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2017
1	Interleukin-17 (Interleukin 17)IBA 04/2016
1	InterferonsIBA 04/2016
1	tempolIBA 01/2016
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 01/2016
1	Oxidants (Oxidizing Agents)IBA 01/2016
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2016
1	2-(aminomethyl)phenolIBA 01/2016
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 10/2015
1	Indicators and Reagents (Reagents)IBA 08/2015
1	Glutamate Receptors (Glutamate Receptor)IBA 08/2015
1	Vasopressins (Vasopressin)IBA 08/2015
1	Interleukin-10 (Interleukin 10)IBA 08/2015

Therapy/Procedure

2	Therapeutics 01/2020 - 03/2012
2	Nephrectomy 12/2019 - 02/2010
1	Drug Therapy (Chemotherapy) 01/2017